UK gets biggest-ever grant from National Institutes of Health to probe links between obesity and cardiovascular disease

The University of Kentucky has received its largest-ever National Institutes of Health grant to explore connections between two of the state's biggest health problems, obesity and cardiovascular disease.

Dr. Lisa Cassis
directs the program.

The university's Center of Biomedical Research Excellence "supports research of promising junior faculty focused on identifying mechanisms linking the epidemic of obesity to a high prevalence of cardiovascular diseases," a UK press release said. The faculty support helps the researchers compete for new NIH grants. In the first phase of the program, 90 percent competed successfully, and they published 500 study reports.

"Research to be executed under the present grant runs the gamut from laboratory research conducted at the cellular level, to bedside translational research conducted in pediatric and adult patients," the release said. "Projects focus on mechanisms for the development of obesity, the influence of obesity on recovery of the heart following a heart attack, obesity-induced inflammation, and how this influences the cardiovascular system, and imaging of heart dynamics and function in obese children."

UK's Gill Heart Institute joins Appalachian Regional Healthcare to advance specialty heart care in Eastern Kentucky

Appalachian Regional Healthcare, the Appalachian Heart Center and UK HealthCare’s Gill Heart Institute announced a new collaboration to deliver cardiovascular care to Eastern Kentuckians, which will extend the UK's sub-specialty care footprint and increase access to cardiovascular expertise in the area.

Cardiologists Dr. Vidya Yalamanchi, Dr. Rao Podapati and Dr. Srini R. Appakondu from Hazard's Appalachian Heart Center will team up with UK to provide advanced treatment options not before available in the eastern part of the state.

“We look forward to the opportunity to work closely with the physicians and health care providers at Gill Heart Institute to enhance cardiology services to patients in Eastern Kentucky,” said Dr. Yalamanchi. “This partnership is an example of teamwork that emphasizes a commitment to providing exemplary patient care.”

In addition to the combined efforts in Hazard, UK and ARH have also agreed to jointly administer and manage cardiovascular services at ARH hospitals in Harlan, Whitesburg, McDowell, Hyden and Williamson, W.Va.

 “The goal of this collaboration is to expand the scope of cardiology services provided within our community,” said Joe Grossman, president of ARH. “By providing a range of comprehensive cardiology services, including inpatient and outpatient services to residents of Eastern Kentucky, we hope to improve lives in a region where patients suffer from some of the highest rates of mortality in the nation from heart disease and stroke.”

UK officials have said their hospital must expand its geographical reach to ensure access to quality care for Kentuckians. This collaboration represents a step towards achieving both this goal and the goal of being the hospital destination for sub-specialty care in the state and region.

“This alliance further expands the UK HealthCare mission to improve access to quality health care delivery for all Kentuckians in a cost effective and responsible manner,” Dr. Michael Karpf, UK executive vice president of health affairs, said in the release. “But the real benefit for many patients and their loved ones will be the ability to stay close to home for complex cardiology care.”

Chief of cardiothoracic surgery and pediatric heart program at UK, suspended from surgeries, takes job in Florida

Dr. Mark Plunkett, the chief University of Kentucky cardiothoracic surgeon whose surgery program was suspended last year for unspecified reasons, has accepted a new job a the University of Florida.

The internal review of UK HealthCare's pediatric cardiothoractic program is ongoing and should be completed in the next few weeks, Michael Karpf, UK's executive vice president for health affairs, told Linda Blackford of the Lexington Herald-Leader.

In December, Brenna Angel, reporter for university radio station WUKY, identified Plunkett as the surgeon at the center of the program review. At the time, Plunkett was on a leave of absence but remained on staff with a $700,000 salary, Angel reported. WUKY requested data under the Kentucky Open Records Act about Plunkett's most recent surgery and his patient mortality rate, but UK denied such requests. Attorney General Jack Conway ruled that UK must release the mortality rates and other data, but UK Has appealed to Fayette Circuit Court, citing privacy rules in the federal Health Insurance Portability and Accountability Act, even though Conway said HIPAA doesn't preempt the Open Records Act, as Angel reported. Angel has since left the station for Lexington city government but the station and the Herald-Leader are defending the appeal.

In addition to being chief of UK's Division of Cardiothoracic Surgery, Plunkett was director of its pediatric cardiac program and a co-director of UK's Gill Heart Institute, says his UK biography. He came to UK in 2007 from the UCLA medical center, where he worked with Karpf. His resignation is effective Aug. 14, UK officials told Blackford.

UK Board of Trustees OKs $31 million plan to outfit another floor of new hospital with eye toward federal certification for heart work

The University of Kentucky Board of Trustees has given UK HealthCare the green light for its $31 million plan to outfit the eighth floor of Pavilion A at UK Chandler Hospital over the next few months to make room for a growing cardiovascular program and to clear the way for a federal "Center of Excellence" certification.

After the project is complete, the floor will hold 64 beds, including 24 intensive-care beds for the cardiovascular program that offers heart transplantation, artificial hearts and ventricular devices, reflecting UK's focus on receiving the federal certification.

In the near future, such a designation will be necessary to get enough referrals from doctors and smaller hospitals to maintain important services, including cardiovascular services, and to guarantee that Kentuckians can get the care they need inside the state, Dr. Michael Karpf, executive vice president for health affairs, said in an interview with Kentucky Health News this spring.

Karpf and other UK HealthCare officials are also recommending a $30 million cost-reduction program for their system because Medicare and Medicaid reimbursements are expected to decline as competition stiffens over the next few years, reports Linda Blackford of the Lexington Herald-Leader.

In response to these forces, UK has a goal to secure half the available business from out-of-state competitive areas over the next 10 years to remain viable in a highly competitive market. And, focusing on complex care should drive revenue for the hospital because UK makes money on the complex stuff, Karpf told KHN.

Read more here: http://www.kentucky.com/2013/06/10/2673382/uk-healthcare-using-30-million.html#storylink=cpy

The $592 million, 12-floor patient tower has remained half-empty since 2010, and when the estimated $530 million project to fully occupy the tower is added to the initial cost of constructing Pavilion A, the total price tag will top $1 billion over 20 years, reports Blackford.

The overall construction and expansion is expected to support patient care for the next 100 years, says a recent UK press release. Once it's fully occupied, the the 1.2 million-square-foot facility will include 512 private patient rooms.

Read more here: http://www.kentucky.com/2013/06/10/2673382/uk-healthcare-using-30-million.html#storylink=cp

Small steps can prevent Kentucky's No. 1 killer, heart disease

It is now February, which is American Heart Month and a perfect time to remind people that small steps can reduce their risk of heart disease, Kentucky's No. 1 killer.

You may be surprised to hear that almost 80 percent of heart disease is preventable and there are daily things that can be done to keep hearts healthy, according Dr. Martha Grogan, medical editor-in-chief of Mayo Clinic Healthy Heart for Life.

For example, try to move 10 extra minutes each day, Recent research shows a sedentary lifestyle may increase your risk of heart attack almost as much as smoking, said Grogan.

Each day, make an effort to get up from your desk to go talk to a colleague instead of sending an email, or walk around the house as you are talking on the phone, she recommends: “Moving even 10 minutes a day for someone who’s been sedentary may reduce the risk for heart disease by 50 percent.”

Hearts are also hurt when you deprive yourself of sleep, which is a necessity like food and water, said Virend Somers, a Mayo cardiologist and sleep expert. Chronic sleep deprivation can increase the risk of obesity, high blood pressure, heart attack, diabetes and depression.

Healthy habits can reduce a majority of risks for heart attack. "A 53-year-old male smoker with high blood pressure has a 20 percent chance of having a heart attack over the next 10 years. If he stops smoking, his risk drops to 10 percent; if he takes high blood pressure medicine, it falls to 5 percent," says preventive cardiologist Randal Thomas, M.D.

These healthy habits and changes like quitting smoking and taking blood pressure medicine can make a difference in life and death. For more from the Mayo Clinic, click here; for a American Heart Month information from the federal Centers for Disease Control and Prevention, go here.

British researchers say a simple calculation can predict likelihood of a baby's chance of becoming obese during childhood

If only we knew from the start which babies were predisposed to becoming diabetic and hypertensive and overweight . . . News out this week suggests we can. NBC News reports that British researchers have published findings in the journal PLOS ONE saying that a simple assessment can predict at birth a baby's likelihood of becoming obese during childhood. The formula, available as an online calculator here, estimates the child's obesity risk based on its birth weight, the body mass index of the parents, the number of people in the household, the mother's professional status and whether she smoked during pregnancy.

The hope is to help families will take steps to control the weight of babies and small children before medical problems arise. Philippe Froguel of Imperial College London, who led the study, explained that teaching parents about the dangers of over-feeding and bad nutritional habits at a young age is much more effective than having to teach children how to lose weight. Froguel's team developed their formula following 4,000 Finnish children since 1986. Childhood obesity is a leading cause of early type 2 diabetes, as well as various types of cardiovascular disease. (Read more)

U of L doctor tells American Heart Association that cardiac stem-cell research shows a lot of promise

Dr. Roberto Bolli

Promising results are coming from research that uses patients’ own cardiac stem cells to heal their hearts, a Louisville doctor told colleagues this week at an American Heart Association meeting in Los Angeles.

Laura Ungar of The Courier-Journal reports that Dr. Roberto Bolli, lead author of the clinical trial and chief of cardiovascular medicine and director of the Institute of Molecular Cardiology at the University of Louisville, said cardiac stems cells may someday be used to treat heart failure caused by muscle scarring after a heart attack.

Bolli, who partnered with Dr. Piero Anversa of Brigham and Women’s Hospital in Boston on the research, explained that their research showed that hearts in patients treated with their stem cells had greater pumping power, and benefits continued to increase as long as two years after receiving the cells.  Heart failure afflicts about 6.6 million Americans. (Read more)

Use of pacifiers could lead to very sick babies, study finds

Oklahoma State University researchers report that they have found a wide range of disease-causing bacteria, fungus and mold on pacifiers that young children had been using.

In research presented at the American Society for Clinical Pathology, scientists have shown that pacifiers can also grow a slimy coating of bacterial film that alters the normal bacteria in a baby or toddler's mouth, increasing the likelihood of colic and ear infections. It gets worse, according to study author Tom Glass, a professor of forensic science, pathology and dental medicine: The same types of bacteria found on a common pacifier have been linked to cardiovascular disease, metabolic syndrome, allergies, asthma and autoimmune diseases.

HealthDay reporters Barbara Bronson Gray writes that Glass said the problems associated with pacificers are also applicable to any removable orthodontic appliance like retainers, mouth guards and dentures. Glass said his researchers were particular concerned about their findings when they discovered that "many of the bacteria growing from the used pacifiers were resistant to commonly used antibiotics such as penicillin and methicillin. The development of such resistance to certain antibiotics does not cause the organism to be more infectious than other strains that have no antibiotic resistance, but it can make the infection more difficult to treat." Glass told Gray that he does not recommend that pacifier use. use. "After doing the study, I say why take a risk?" (Read more)

Cardiologist: Kentucky needs better way to get heart attack patients to dedicated catheterization centers in time

Because cardiovascular disease kills more Kentuckians than anything else, and because what mostly kills them is a heart attack, and because if you can get help within 90 minutes of that heart attack your chances improve dramatically, this state needs a vastly improved way to get heart attack patients to the right hospital in a short amount of time. So explains Dr. William Dillon, an interventional cardiologist in Louisville, who writes an guest column in the In The Prime health blog of The Courier-Journal. He punctuates his point with a graph, right, that shows that Kentucky now ranks 49th of 50 states in acute myocardial infarction (AMI) deaths. AMI is doctor-speak for heart attacks. (American Heart Association graph)

Dillon's medically reasoned plea is for a more systematic regional network -- like one that have saved lives in North Carolina -- is "to transfer AMI patients to dedicated (heart catheterization lab) centers throughout the state." But Dillon also knows that many Kentuckians are not listening to their bodies as closely as they might. He writes that "another source of delay in AMI treatment is that, on average, patients wait more than 90 minutes before seeking medical attention. Furthermore, 50 percent of AMI patients drive to a hospital or clinic without calling EMS. Every year, a significant number of these patients needlessly die en route to the hospital." He adds then that health education -- in this case, early notification of needing EMS help -- is an important component in saving Kentuckians' lives. (Read more)

UK and Purdue researchers find a compound in watermelon that fights 'bad' cholesterol and arterial plaque in lab rats

A study from the University of Kentucky and Purdue University showed that mice fed a diet including watermelon juice had lower weight, cholesterol and arterial plaque than a control group. The findings, reported in the Journal of Nutritional Biochemistry, suggest that citrulline, a compound found in watermelon, plays a role in cardiovascular health. "We were interested in citrulline because previous studies showed that it may lower blood pressure,"  Shubin Saha, a Purdue Extension vegetable specialist and study co-author, told Medical Xpress. "We didn't see a lowering of blood pressure, but these other changes are promising."

"The researchers fed two groups of mice diets high in saturated fat and cholesterol," MX reports. "Half the mice received water containing 2 percent watermelon juice, while the others received the same amount of water supplemented with a solution that matched the carbohydrate content of the watermelon juice. The mice that consumed watermelon juice gained about 30 percent less weight than the control group and had about 50 percent less LDL cholesterol - the so-called bad cholesterol. The experimental group also had about a 50 percent reduction in plaque in their arteries, as well as elevated levels of citrulline." Sibu Saha, a professor of surgery at UK, explained that the researchers are not sure at what molecular level the citrulline is working, but that is their next step.

Shubin Saha was excited about the dual benefit of the findings. "Twenty percent of each year's watermelon crop is wasted either because the fruit is visibly unappealing to consumers or because some growers find it too expensive to pay for harvesting as prices drop during the height of watermelon season." The wasted melons, he explained, could be put to use extracting these very beneficial compounds.  (Read more)

KET talks with experts on heart disease and health reform tonight

Some nationally recognized heart specialists will speak directly to Kentuckians about heart disease tonight on the season premiere of Health Three60 on KET. Cardiovascular disease, the leading cause of death in the United States -- and, perhaps surprisingly, in women -- will get a thorough examination. The show will take on the history of the disease, what women should know about the disease and what the future looks like for all of us. Host Renee Shaw will explore the history of cardiac surgery and the development of the artificial heart with Dr. Laman Gray, Jr. cardiovascular surgeon and medical director at the Cardiovascular Innovation Institute. Gray will also discuss how the death rate from heart disease has decreased even as the increase has gone up.

Guests will also include Dr. Joey Maggard, executive director of the Central Kentucky Chapter of the American Heart Association; Dr. Melissa Walton-Shirley, cardiologist with Cardiology Associates in Glasgow; Mark Rucker, recipient of the American Heart Association Lifestyle Change Award; Dr. Paula Hollingsworth, cardiologist at Central Baptist Hospital in Lexington; and, James B. Hoving, Ph.D., division chief of cardiosvascula therapeutics at the Cardiovascular Innovation Institute. Health Three60 airs at 9 p.m. EDT.

Immediately preceding Health Three60, on this week's edition of Kentucky Tonight, host Bill Goodman and guests will discuss health care and health care reform.  Scheduled guests include State Sen. Tom Buford, R-Nicholasville, chair of the Senate Banking and Insurance Committee; State Rep. Mary Lou Marzian, D-Louisville, vice chair of the House Budget Review Subcommittee on Human Resources; Dr. Ralph Alvarado, a Winchester internist and pediatrician; and Dr. Barbara Casper, an internist and University of Louisville professor of medicine. Kentucky Tonight airs at 8 EDT.

U of L researcher gets $3.4 million to replicate studies of stem cells for heart treatment

Dr. Roberto Bolli of the University of Louisville has received a $3.4 million grant from the National Institutes of Health to test the validity of several recent studies by replicating them. The studies examine whether certain types of stem cells are safe and effective in treating heart failure, heart attacks and other cardiovascular disorders.

"Replicating studies in several locations with a large number of patients is necessary for researchers to ultimately determine which ones can be submitted to the Food and Drug Administration for approval," Jill Scoggins reports in a U of L press release.

Bolli has received more than $100 million in grants for basic research for NIH. This is the first grant he has been awarded for clinical research. (Read more)

U of L scientist wins $9.5 million for heart research

A University of Louisville scientist has received more than $9.5 million from the National Heart, Lung and Blood Institute to conduct promising new cardiovascular research.

Dr. Roberto Bolli, right, aims to find a drug that would reduce heart damage during a heart attack, The Courier-Journal's Laura Ungar reports.

Bolli will also work with scientists at John Hopkins University in Baltimore, Emory University in Atlanta and Virginia Commonwealth University in Richmond to conduct the research.

Kentucky Department for Public Health numbers show 10,000 Kentuckians died from heart disease in 2005. (Read more)